SSCT 2011 workshop

The 28th Workshop of SSCT and the FINCOPA Seminar

"Towards toxicity assessment without animals"

Call for Papers

Time: Wednesday 21^st – Friday 23^rd September 2011
Place: Tampere, Scandic Rosendahl, Tampere, Finland

Welcome to Tampere to the 28^th Workshop of SSCT and Fincopa Seminar!

Dear Colleagues,

The 28th workshop of Scandinavian Society for Cell Toxicology (SSCT) will be organized as a joint meeting with the Finnish Consensus Platform for Alternatives (Fincopa) 21-23 September 2011 in Tampere. The theme is “Towards toxicity assessment without animals”.

We live in a chemical world. However, the safety of the chemicals to man and the risks to the environment have been studied for only a fraction of the chemical substances. The pressure to perform toxicity assessment without animals comes from various stakeholders: regulatory guidelines such as Cosmetic directive prohibit the use of animals in assessing the safety of cosmetics or cosmetic ingredients, and REACH calls for non-animal tests to be performed when ever possible, European Commission´s goal is to decrease the use of laboratory animals, industry wants cheaper and more reliable test methods than animal experiments. Today, the toxicity assessment is mostly performed with animals, but more and more robust alternative (in vitro) tests are being developed. The developing science, use of human cells and novel tissue engineering as well as instrumentation solutions have made possible the change from in vivo to in vitro testing .

The Fincopa seminar, free and open to all participants, will concentrate on the status of new in vitro methods covered by EU-FP-7-project to replace/supplement animal experiments.

The 28^th SSCT workshop will start with the new updated directive of 2010/63/EU (22.09.2010) and its impact on the toxicity testing strategy, followed by presentations on in vitro methods from scientific and technical perspectives. The other topics cover:

-          A new paradigm: Away from histopathology-based toxicity assessment
-          Optimal in vitro cellular model
-          Significance of barriers in toxicity risk assessment

Advanced technical solutions are of utmost importance for successful cell culture research and test development. The area is developing very fast. To bring scientists up to date with new technical solutions a commercial exhibition will be organized in connection with the workshop.

We are looking forward to have a meeting with up-to-date scientific knowledge. We wish you warmly welcome to Tampere and call you to send abstracts to be presented as oral presentations or as posters.

On behalf of the Organizers

Tuula Heinonen
President, SSCT

Programme:

Wednesday, September 21, 2011

08:00 –	REGISTRATION
09:00 – 09:15	Opening Tuula Heinonen, FICAM, University of Tampere, FI
09:15 – 12:00	Session 1: Status of EU-projects and new developments to replace animal experiments Chair: Horst Spielmann, Freie Universität Berlin, DE
09:15 – 10:00	Status of EU-projects and new developments in reproductive toxicity assessment Horst Spielmann, Freie Universität Berlin, DE
10:00 – 10:30	Assessment of carcinogenic and mutagenic potency of chemical substances: present status and future perspectives Tuula Heinonen, FICAM, University of Tampere, FI
10:30 – 10:45	COFFEE BREAK
10:45 – 11:15	Multivariate analyses of in vitro data from the ACuteTox project using human toxicity data Cecilia Clemedson, AdvocoTox consulting AB, SE
11:15 – 11:45	ECVAM prevalidation study on skin sensitisation alternatives: progress update David Basketter, DABMEB Consultancy Ltd, Sharnbrook, UK
11:45 – 12:15	Toxicokinetics: a key to the toxicity risk assessment based on non-animal approaches Olavi Pelkonen, University of Oulu, FI
12:15 – 13:00	LUNCH (SSCT board meeting)

13:00 – 18:00	Session 2: Impact of the Council adopted Updated Directive 86/609/EEC 2010/63/EU Chair: Joachim Kreysa, ECVAM, JRC, IT and *Tuula Heinonen, FICAM, University of Tampere, FI*
13:00 – 13:45	EU-perspective Susanna Louhimies, EU - DG Environment, BE
13:45 – 14:30	ECVAM-perspective Joachim Kreysa, ECVAM, JRC, IT
14:30 – 15:15	Implementation in Finland Kai Pelkonen, Kai Pelkonen Consulting Ltd, FI
15:15 – 15:45	COFFEE BREAK AND POSTER VIEWING
15:45 – 16:15	Use of non-animal models in regulatory science: challenges & opportunities Derek Knight, ECHA, FI
16:15 – 16:45	Neuronal cells differentiated from human embryonic cells and iPS cells as building blocks for functional models Outi Hovatta, Karolinska Institutet, SE
16:45 – 17:15	Nanoparticles as ecotoxicological threat Anne Kahru, National Institute of Chemical Physics and Biophysics, EE
17:15 – 17:35	Evaluation of the effects of environmental chemicals on endothelial tubule formation in an in vitro angiogenesis assay Riina Sarkanen, FICAM, University of Tampere, FI
17:35 – 17:55	Decreased chemical risk may lead to increased microbiological risk Elina Kähkönen, Aalto University, FI
18:00 – 20:00	GET TOGETHER Welcome Perttu Pesä, Deputy Mayor of the City of Tampere

Thursday, September 22, 2011

09:00 – 12:30	Session 3: A new paradigm: Away from histopathology based toxicity assessment Chair: Thomas Hartung, Johns Hopkins University – CAAT, US
09:00 – 09:45	Toxicity testing in the 21st century Thomas Hartung, Johns Hopkins University – CAAT, US
09:45 - 10:30	Critical toxicity pathways – How to identify? Robert Kavlock, EPA, US
10:30 – 11:00	COFFEE BREAK
11:00 – 11:45	Critical biomarkers for estimation of acute neurotoxicity by using in vitro models Anna Forsby, Stockholm University, SE
11:45 – 12:30	How to add metabolism into the in vitro cellular system Olavi Pelkonen, University of Oulu, FI
12:30 – 13:30	LUNCH
13:30 – 17:30	Session 4: Optimal in vitro cellular model Chair: Timo Ylikomi, FICAM, University of Tampere , FI
13:30 – 14:00	In vitro - in vivo extrapolation of toxic potencies: basic requirements Hasso Seibert, University Medical School, Schleswig-Holstein DE
14:00 - 14:30	Optimal matrices Timo Ylikomi, FICAM, University of Tampere, FI
14:30 - 15:00	A breakthrough in biomaterial development for 2D-3D cellular models: Native plant cellulose nanofiber hydrogels support 3D cell spheroid formation without bioactive matrix components Marjo Yliperttula, University of Helsinki, FI
15:00 – 15:30	COFFEE BREAK AND POSTER VIEWING
15:30 – 15:45	Introduction to the Björn Ekwall Memorial Award Lecture Hanna Tähti, FICAM, University of Tampere, FI
15:45 – 16:30	The Björn Ekwall Memorial Award Lecture Placental transporters: models and mechanisms in toxicology Päivi Myllynen, University of Oulu, FI
16:30 – 18:00	SSCT ANNUAL GENERAL MEETING
18:00 – 19:00	MEETING OF THE NEW SSCT BOARD
19:00	BANQUET

Friday, September 23, 2011

09:00 – 10:20	Session 5: Significance of biological barriers in toxicity risk assessment Chair: Kirsi Vähäkangas, University of Eastern Finland, FI and Bas Blaauboer, University of Utrecht, NL
09:00 – 09:45	The significance of specific barriers in biokinetics: the consequences for toxicological risk assessment of compounds Bas Blaauboer, University of Utrecht, NL
09:45 – 10:15	Use of in vitro models of the BBB for the determination of acute and repeated dose toxicity Romeo Cecchelli, Artois University, Lille, FR
10:15 – 10:45	Placental barrier in toxicology Kirsi Vähäkangas, University of Eastern Finland, FI
10:45– 11:15	COFFEE BREAK
11:15 – 11:35	Placental transport of large molecules – studied using human ex vivo placental perfusion Line Mathiesen, University of Copenhagen, DK
11:35 – 11:55	SkinEthic Laboratories, a validated choice of in vitro alternative methods to the animal use for skin corrosion and irritation and other selected choices for eye irritation, skin genotoxicity and skin pigmentation Alain Alonso, SkinEthic, FR
11:55 – 12:15	Vascularized heart tissue model for cardiac toxicity testing Hanna Vuorenpää, FICAM, University of Tampere, FI
12:15 – 12:35	Biomimetic microsystems for functional in vitro models Pasi Kallio, Tampere University of Technology, FI
12:35 – 12:55	Application of 3D cell culture using alvetex® Terry Sunderland, Biological and Life Sciences, LGC Standards,UK
12:55 – 13:00	CLOSING OF THE WORKSHOP
	DEPARTURE

International Scientific Advisory Committee

Cecilia Clemedson
Anne Forsby
Tuula Heinonen
Ada Kolman
Kimmo Louekari
Aimo Oikari
Olavi Pelkonen
Hasso Seibert
Tore Syversen
Hanna Tähti
Kirsi Vähäkangas

Local Organizing Committee

Heidi Diallo, Secretary General
Tuula Heinonen, Chairperson
Marika Mannerström
Marika Päällysaho
Pauliina Salonen
Kimmo Savinainen
Riina Sarkanen
Tarja Toimela
Hanna Tähti
Hanna Vuorenpää

Workshop Secretariat

Ms. Heidi Diallo
FICAM
School of Medicine
University of Tampere
Medisiinarinkatu 3
FI-33014 University of TampereFinland
Sähköpostiosoite on suojattu roskapostiohjelmia vastaan, Javascript-tuen tulee olla päällä nähdäksesi osoitteen ,
tel: +358 40 8388046
Fax: +358 3 3551 6170

General information

Registration: Deadline for Registration has been extended to August 1, 2011
Late and on-site registrations possible, but dinner requests not guaranteed.
For registration, please fill the registration form and send it to Sähköpostiosoite on suojattu roskapostiohjelmia vastaan, Javascript-tuen tulee olla päällä nähdäksesi osoitteen , Fax: +358 3 3551 6170

Registration fee:
The registration fee covers free admission to both Fincopa Seminar and SSCT workshop, abstract book, refreshments during coffee breaks, get-together party and banquet.

Fee for SSCT- and Fincopa members, before June 15, 2011: 290 Eur
Fee for non-SSCT-and non-Fincopa members, before June 15, 2011: 330 Eur
Fee for SSCT-and Fincopa-members, after June 15, 2011: 390 Eur
Fee for non-SSCT and non-Fincopa-members, after June 15, 2011: 430 Eur
Fee for students: 180 Eur
Fee for one day: 140 Eur

The registration fee should be transferred to the bank account as follows:

Name of bank: Sampo Pankki Oyj Tampere, Hämeenkatu 9, 33100 TAMPERE
Account holder: SSCT WORKSHOP 2011
Account number: 833007-10348768
IBAN number: FI9783300710348768
BIC/SWIFT code: DABAFIHH

Abstract submission:

Deadline for abstract submission has been extended toAugust 1, 2011
Abstract size: one A4 page including title, authors with affiliations, body text with font size 12
Please send the abstract to Sähköpostiosoite on suojattu roskapostiohjelmia vastaan, Javascript-tuen tulee olla päällä nähdäksesi osoitteen

Posters:

The size of the poster stand is height 125 cm and width 95 cm.

Proceedings:

The invited speakers and participants having free oral or poster presentations are invited to submit a paper according to the instructions for authors for the SSCT special issues in Toxicology in Vitro.

All papers will need to be submitted to the EES system of the journal, and labeled as “SSCT 2011 special issue” in the “article type name” field.

All instructions to authors that are listed in the EES system also apply, with the following additions:

1. The papers should clearly be related to the presentations made during the SSCT 2011 meeting in Tampere, according to the judgment of the guest editors.

2. There are restrictions to the length of the articles:
- for papers submitted by invited speakers: 20 pages double-spaced print, and including all materials, e.g. reference list, figures and tables
- for papers submitted by other oral presenters and poster presenters: 15 pages double-spaced print, and including all materials, e.g. reference list, figures and tables

The guest editors (T. Heinonen and H. Tähti) together with the European Editor (B. Blaauboer) will act as the editors for this special issue.

Workshop Venue and Transportation:

The venue of the Fincopa-28th SSCT-workshop will be a beautiful conference centre of Scandic Rosendahl (www.scandichotels.com/rosendahl) located by the magnificent scenery of Lake Pyhäjärvi and the Pyynikki ridge. Even only 3 kilometers from Tampere city centre Scandic Rosendahl provides the peace and quiet of nature for the visitors. The participants are asked to book the accommodation themselves either in the Scandic Rosendahl or in some other hotels (see the Hotel info below).

Address for Hotel Scandic Rosendahl is Pyynikintie 13, 33230 Tampere, tel: +358 3 2441 111, Fax: +358 3 2441 2211, Sähköpostiosoite on suojattu roskapostiohjelmia vastaan, Javascript-tuen tulee olla päällä nähdäksesi osoitteen

You can reach Scandic Rosendahl by bus number 21 from the city center with the costs of 2.5 Eur or by taxi with approximately 15 Eur.

Tampere is easy to reach by plane or by train from various cities in Finland including Helsinki (1-2 trains per hour taking 1.5 hours). There are also straight international flight connections e.g. between Stockholm and Tampere.

Hotel Info:

The organizers have reserved rooms in Scandic Rosendahl with lower room rate than normal and with the code `SSCT 2011`. This reservation is valid until 20 July 2011. The participants are asked to make their own hotel reservations. Please mention the code when making the reservation.

If the participants prefer to make their hotel reservation in other hotels in Tampere, please contact hotels in Tampere city directly, e.g. www.hotels.com/tampere or http://www.booking.com. There is a good local bus connection between the Scandic Rosendahl and other parts of Tampere city.

Social Programme:

Wednesday 21st September at 6 pm. Get together party, included in the registration fee, will be organized in the workshop venue (Scandic Rosendahl)

Thursday 22nd September at 7 p.m. Symposium Dinner (included in the registration fee) takes place at Scandic Rosendahl.

Commercial Options:

1) Exhibition fee of 450 euros for 5m2 and 900 Eur for 10m2. In addition 100 euros for advertisement in programme/abstract book. Distribution of brochures included

2) Advertisement in the programme/abstract book 350 Eur for ½ page

Advertisement in the programme/abstract book whole page 500 Eur for whole page. Distribution of brochures included.

3) Name on the Sponsor list in the programme/abstract book, 250 Eur. Distribution of brochures included.

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The 29^th Workshop of SSCT and the FINCOPA Seminar